Health News

Oct 2, 2025

How sweeteners help keep weight off long term

Replacing added sugar with sweeteners may help maintain weight loss and support a healthy gut, according to new research on diet and metabolism.

If you have ever tried to lose weight, you probably know that keeping the weight off can be just as challenging as losing it. Many people celebrate after dropping pounds, but soon find that the weight slowly creeps back. Scientists have been searching for ways to help people maintain their weight loss, and new research is showing that what you swap for sugar might make a big difference in the long run.

Why sugar is tricky for weight maintenance

Sugar tastes delicious, but eating too much of it can make it hard to keep weight off. The World Health Organization recommends limiting added sugars in foods and drinks because they are linked to health problems like obesity and diabetes. But simply cutting out sugar is difficult for most people, especially since so many foods and drinks have sugar added to make them taste better. This is why researchers are exploring alternatives, like sweeteners and sweetness enhancers, that can give food a sweet taste without all of the calories.

What scientists discovered about sweeteners and weight loss

In a recent 12-month clinical trial, researchers wanted to know if replacing added sugar with sweeteners and sweetness enhancers could help people who had already lost weight avoid gaining it back. The study, which included several research centers and hundreds of participants, found that swapping sugar for sweeteners supported modest weight loss maintenance and even changed the types of bacteria living in people’s guts (see the Nature Metabolism study here). Importantly, the researchers did not find any safety concerns linked to using these sweeteners over the course of the year.

How sweeteners may affect your gut microbiome

The gut microbiome is made up of trillions of bacteria and other tiny organisms that live in your digestive system. Scientists are learning that the microbiome can affect everything from digestion to how our bodies handle calories. In the clinical trial, people who used sweeteners instead of sugar had changes in their gut microbiota. This means that sweeteners might not just help with cutting calories; they could also shape the types of bacteria in your gut, which may play a role in maintaining a healthy weight. For more on how changes in fat cells and metabolism can impact health, check out this SlothMD article on how weight loss transforms fat tissue.

Are sweeteners safe and effective for everyone?

One of the most important findings from this research is that using sweeteners and sweetness enhancers instead of added sugars did not lead to any safety issues over 12 months. This is good news for people who want to make healthier choices but still enjoy sweet foods and drinks. However, scientists are still studying exactly how different types of sweeteners work in the body. Some earlier studies have looked at how non-sugar sweeteners affect metabolism, appetite, and gut bacteria, with mixed results (read more about sweeteners and gut health in this Cell study). So, while sweeteners can be a helpful tool, it is still best to use them in moderation and as part of an overall healthy eating plan.

What this means for your health and diet choices

If you are working to keep weight off after losing it, replacing sugary foods and drinks with those that use safe sweeteners may give you an extra boost. Not only do you cut out some calories, but you might also be supporting a healthier gut, which could help you maintain your progress over time. For more about how the body’s fat cells adapt and change, even in animals, you might enjoy this SlothMD article about cow fat cells and metabolism.

Looking ahead: The future of weight loss maintenance

While there is no magic fix for weight loss maintenance, research like this is helping us understand which small changes can make a difference. Health AI platforms like SlothMD are making it easier for people to get personalized advice based on the latest science. As we learn more about how sweeteners work in the body, and how our gut microbiome affects weight, we can make smarter choices to stay healthy for the long term. If you are curious about new developments in diet and metabolism, keep an eye out for more updates from health news and trusted sources.

If you are thinking about making changes to your diet, always talk with a healthcare professional, especially if you have any medical conditions. Everyone’s body is different, and what works for one person might not work for another. But with the help of new research and health AI tools like SlothMD, staying healthy and keeping weight off may get a little bit easier.

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©2025 — 360H, Inc.

*We are not affiliated, associated, or endorsed by any of the companies whose logos appear on this site. Their trademarks are the property of their respective owners, and any mention or depiction is solely for informational purposes.

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